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pentobarbital will decrease the level or effect of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration. Robust or average CYP3A inducers might lower cobimetinib systemic exposure by >eighty% and reduce its efficacy.pentobarbital will reduce the extent or effect of buprenorphine subd

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